I-95 Southbound: Exit 74B - Franklin St. At end of ramp, cross Franklin on to 15th Street. Turn left at the next light on to East Main Street. The Edgar Allan Poe Museum is located 4 blocks east on the left-hand side. The Museum's parking lot is next to the Museum at the corner of East Main & 20th Streets.

I-95 Northbound: Exit 74C - East Broad St. Bear right (Route 33) as the exit ramp splits. This will lead you onto 17th St. Move over to the left lane as soon as possible. Make a left turn onto Broad Street at the next traffic light. Proceed through the next traffic light (18th Street) and make a right turn onto 20th Steet. Proceed through the next two stop signs (E. Grace & E. Franklin Streets). The museum's parking lot will be on your right at the corner of East Main & 20th Streets.